How to Read "ADHD Drug Evidence Is Weak" Headlines — Cochrane Systematic Review (2023)

Target: Children/adolescents with ADHD (multiple RCTs included) Type: SystematicReview Grade: B

3-Line Summary

  1. What: Cochrane rated the certainty of evidence for methylphenidate as "very low."
  2. Who: Risk of bias, under-reporting of side effects, and study heterogeneity were the main reasons.
  3. Result: This means "hard to say with certainty," not "it doesn't work."

Keywords

methylphenidate Cochrane evidence-certainty very-low-certainty bias

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